Global Research
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Research Across The Globe
Several research projects are actively investigating CRB1-related retinal diseases, focusing on understanding disease mechanisms and developing potential therapies. Notable projects include:​
- Human Retinal Organoids for CRB1 Retinopathy
- Principal Investigator: Dr. Brian Ballios
- Institution: University Health Network​
- Funding: $66,991​Â
- Objective: Utilizing patient-derived stem cells to create retinal organoids that model CRB1 disease, aiming to identify disease mechanisms and test potential therapies.
- Targeting Retinoid Traffic for CRB1 Degenerative Disorders
- Principal Investigator: Dr. Konstantin Petrukhin
- Institution: Columbia University Medical Center​
- Funding: $40,177
- Objective: Investigating the role of retinoid trafficking in CRB1-related retinal degenerations to identify novel therapeutic targets.
- Characterization of CRB1 Patient iPSC-Derived Retinal Organoids
- Principal Investigator: Dr. Jan Wijnholds
- Institution: Leiden University Medical Center​Â
- Funding: $40,177​
- Objective: Developing potency assays for gene therapy by characterizing retinal organoids derived from CRB1 patients’ induced pluripotent stem cells.
- AAV Gene Therapy on Cultured Human iPSC-Derived Retina
- Principal Investigator: Dr. Jan Wijnholds​
- Institution: Leiden University Medical Center​
- Funding: $50,312​Â
- Objective: Exploring adeno-associated virus (AAV) gene therapy approaches on human iPSC-derived retinal cultures lacking CRB1 and CRB2.Â
- CRB1-Null Human Retinal Organoids for Disease Modeling
- Principal Investigator: Dr. Wei Liu
- Institution: Albert Einstein College of Medicine
- Funding: $50,312
- Objective: Creating CRB1-null retinal organoids to model the disease and assess gene therapy strategies.Â
Pedaling Toward a Cure For CRB1
These projects are supported by grants from the Orphan Disease Center’s Million Dollar Bike Ride initiative, reflecting a concerted effort to advance CRB1-related retinal disease research.
The Curing Retinal Blindness Foundation is a powerhouse in the fight against CRB1 retinal disease, actively fundraising through the Million Dollar Bike Ride to fuel groundbreaking research. Every dollar raised goes directly toward cutting-edge projects developing life-changing treatments and potential cures for those living with CRB1-related blindness. By supporting this mission, you’re not just funding research—you’re investing in a future where blindness from CRB1 mutations is no longer a life sentence. Join us in the fight today!